Nensy Anggrainy, Desvita Sari, MMDEAH Hapsari, Nahwa Arkhaesi, Helmia Farida
OBJECTIVE: Candidemia is the most common manifestations of invasive candidiasis. Incidence of candidemia have been increasing in almost all over the world. Several studies had been conducted to determine the risk factors of candidemia, however, in Dr.Kariadi Hospital only limited data are available.This study aimed to obtain the incidence and risk factors of candidemia in pediatric patients hospitalized in Dr.Kariadi Hospital, Semarang. METHOD: A retrospective study was performed by collecting primary data from Microbiology Laboratory logbook and medical records from January 2017 to December 2018 of pediatric patients hospitalized in Dr. Kariadi Hospital. Risk factors studied were the use of antibiotic for more than 7 days, use of corticosteroids, use of cytostatics, malignancy, neutropenia, surgery, blood transfusion, intensive care treatment, and Total Parenteral Nutrition. Statistical tests that used were X2, Fisher-Exact where appropriate, and logistic regression. RESULT : The incidence of candidemia was 4.3% (33 positive candida out of total 762 blood culture). Risk factor analysis involving 33 positive candidemia and 33 negative candidemia of age-matched patients resulted in malignancy as a significant risk factor for candidemia (OR 2.604; 95% CI 0.911 – 7.445). The use of cytostatics (OR 0.325; 95% CI 0.119-0.888), corticosteroid (OR 0.236; 95% CI 0.077-0.772), surgery (OR 1.134; 95% CI 0.425-3.026), blood transfusion (OR 0.718; 95% CI 0.231-2.229 p=0.566), use of antibiotic (OR 0.414; 95% CI 0.140-1.230),neutropenia (OR 0.283; 95% CI 0.102-0.783 p=0.013),intensive care treatment (OR – ; 95% CI –) and total parenteral nutrition (OR -; 95% CI –) were not significant risk factors. CONCLUSION: The incidence of candidemia in pediatric patients was low. Malignancy is a risk factor of candidemia in pediatric patients in Dr.Kariadi Hospital, Semarang.