Lutvia Hidayati, Henry Wicaksono, Dwiyanti Puspitasari, Leny Kartina, Dominicus Husada, Parwati S. Basuki, Ismoedijanto
OBJECTIVE: The consequences of rubella infection in-utero are referred as the congenital rubella syndrome (CRS). CRS affects almost all ocular structures, either in isolation or in combination. Rubella cataract is the most common ocular sign. The purpose of this study was to identify laboratory confirmed CRS among of infants with congenital cataract. METHOD: A cross sectional study was applied. Data of infant with suspects CRS were collected from 2014-2018 in Dr. Soetomo Academic General Hospital, Surabaya. Infant who diagnosed as congenital cataract and laboratory confirmed CRS were evaluated. Diagnostic of congenital cataract was established by ophthalmologist. Laboratory confirmed CRS was defined as rubella IgM antibody detected for infants less than 6 months of age, while for infants 6 months but less than 12 months of age, rubella IgM and IgG antibody detected, or a sustained rubella IgG antibody level, as determined on at least two occasions at least one month apart in the absence of receipt of rubella vaccine or exposure to wild-type rubella. Chi-square test was used to analyze data. RESULT: From total 506 infants with suspect CRS, there were 90 (18%) diagnosed as congenital cataract. Among them, 60% were female, 60% were less than 6 months of age, 40% were preterm, and 28.9% were low birth weight. Laboratory confirmed CRS was found in 48/90 (53%) infants with congenital cataract. Congenital cataract was risk factor for laboratory confirmed CRS with RR 3.5684 (P<0.001: 95%CI 2.862 to 4.918). CONCLUSION: Infant with congenital cataract was a risk factor about three times higher to get laboratory confirmed CRS.