Abstract Ref Number = APCP171
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AIHA: problem of diagnosis
Yetty Movieta Nency Child Health Dept, Diponegoro University Semarang, Hematology Oncology Division
Autoimmune haemolytic anaemia (AIHA) is an immune disorder caused by antibodies directed against unmodified autologous red cells. The disorder may be a primary (idiopathic) or a secondary due to underlying disease. The diagnosis is based on clinical manifestation and laboratory as well. The presence of anaemia in the most important sign. Levels of hemoglobin 3 g / dl - 9 g / dl, the number of leucocytes varies with immature cell (metamelocyte, myelocyte and promielocytes), sometimes with thrombocytopenia. Indirect bilirubin level increases. Sometimes, not all of these specific features are present. Most AIHA are caused by warm antibodies, whereas cold antibodies are less commonly whereas cold antibodies are less commonly detected. While half of the warm antibody-based AIHA are idiopathic anaemias, almost all cold antibody AIHA are secondary anaemias. The appearance of peripheral smear showed a hemolytic process of anisopoicylosytotis, polychromation as well as poicylocytosis and nucleated erythrocytes cell. A positive Direct Neglobulin Test (DAT) examination indicates the presence of antibodies surface / complement of erythrocyte cell surfaces. On this examination there is a reaction erythrocyte cell agglutination of patients with anti-globulin reagents mixed with cells agglutination by anti-IgG shows an erythrocyte cell surface containing IgG.
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