Ref Number = PITIKA-ASPR0446
Dinar Handayani Asri Hariadi, Husnia Auliyatul Umma, Rustam Siregar
OBJECTIVE  : Anemia is defined as hemoglobin below 11 g/dl for children under 5 y.o, and below 11.5 g/dl for children over 5 y.o. Anemia is associated with typhoid fever as it causes abnormal response of bone marrow leading to hemolytic process. Incidence of typhoid fever in Asian countries is 180 to 194  every 100,000 children aged 5 to 15 y.o. The complications occur in 10%, with Case  Fatality  Rate  of 1–4%. Diagnostic test using typhidot Immunoglobulin M Salmonella has sensitivity 79%, and specificity 84%. Due to high mortality rate of typhoid fever and anemia incidence, we investigated the relationship between anemia and typhoid fever complications in pediatric patient at dr. Moewardi hospital. 
METHODS : This retrospective observational study, was conducted by using medical record from March 2014 to March 2019. The subjects were typhoid fever children, 6 months – 18 years old. Sample was collected by consecutive sampling, with inclusion and exclusion criteria. Diagnose was confirmed by positive IgM Salmonella. Data was analyzed with SPSS 23.0. The result was significant if the p value  < 0.05 (CI 95%).
RESULTS : We found 37 thypoid fever children, during the period. Most of them aged 5 y.o. (51.9%), and male was dominant (64.9%). Anemia and abnormal leucocyte count were observed in  67.6% and 35.1%, respectively. Typhoid fever with complications was observed  37.8%. Most of them were hospitalized for at least 5 days (54%). The logistic regression analysis revealed no correlation of thypoid fever complication with anemia and abnormal leucocyte count (p value = 0.959, p value = 0.764). Length of stay was related to typhoid fever complication (p value= 0.026). 
CONCLUSION : In thypoid fever pediatric patients, anemia and abnormality of leucocyte count are not related to thypoid fever complication, however length of stay is related to it.
Keywords: anemia, typhoid fever, leucocyte count.
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