OBJECTIVE: Sepsis is an emergency event that often found in pediatric intensive care unit. Both hypoglycemia and hyperglycemia are common complication of critical illness that happens because of stress reaction from the organ. PELOD2 score can predict the severity of organ dysfunction and PELOD2 score ? 11 related to poor prognosis. Aims of this study to evaluate association between blood glucose level and PELOD2 Score with mortality in PICU patient with sepsis in RSUP Prof Dr.R. D. Kandou Manado.
METHOD: The retrospective study included patients admitted to PICU between January-April 2019. Subjects were sepsis patients without a history of diabetic mellitus. Illness severity and organ dysfunction were determine by PELOD2 score. Hypoglycemia was defined as blood glucose level <45 mg/dL and hyperglycemia was defined as blood glucose level >200 mg/dL. The statistical analysis to evaluate the association between random blood glucose, PELOD2 score and mortality rate was tested with Chi-Square analysis.
RESULT: 131 children diagnosed with sepsis in PICU, consist 73 boys and 58 girls. From 131 children, 31 children have PELOD2 score ?11 and 100 children with PELOD2 score <11. From 31 children with PELOD2 ?11, 18 children have hyperglycemia, with strong association between them (OR 22, 95% CI 7.479-64.713 P=0.000) and 4 children have hypoglycemia (OR 0.1, 95% CI 0.022-0.480 P=0.000). From 131 children, 54 results in death, with 19 of them have hyperglycemia (OR 0.064, 95%CI 0.014-0.284), 5 children with hypoglycemia (OR 3.929, 95% 0.755-20.455). From 54 children results in death, 30 children with PELOD2 >11 (OR 0.011 CI 0.001-0.081) compared 24 children with PELOD2 <11. There was strong association between blood glucose level and mortality rate in patient with sepsis (p-value 0.000).
CONCLUSION: There was a strong association between blood glucose level with PELOD-2 score and outcome of the patient with sepsis.