OBJECTIVE: Type1 diabetes mellitus (T1DM) is one of the most common autoimmune diseases in childhood. Children with T1DM have a higher risk of having comorbidities with other autoimmune diseases such as thyroiditis and hypothyroid. Thyroid Stimulating Hormone (TSH) is a marker of thyroid function test while Anti Thyroid Peroxidase (Anti-TPO) is an autoimmune test for thyroiditis. Therefore, the purpose of this research was to evaluate the relationship between TSH and Anti-TPO in children with T1DM at Dr. Soetomo Academic Hospital.
METHOD: This cross-sectional study was conducted at Dr. Soetomo Academic Hospital Surabaya during January-May 2019 with participants aged less than 18 years with T1DM. Based on the National Academy of Clinical Biochemistry Laboratory Guidelines, the participants were classified as hypothyroid if FT4 is less than 0.9 ng/dL and TSH is more than 10 mIU/mL) and subclinical hypothyroidism if serum FT4 is between 0.9-1.7 ng/dL and TSH is more than 2.50 mIU/mL. Anti-TPO above 30 U/mL were considered to be positive. Pearson correlation was used to analyze data with p <0.05.
RESULT: About 31 children were included, consisting of 17 (17/31) boys with the median age of 11(3-18) years. The mean level of TSH was 2.49 µU/mL (SD±1.81) µU/mL and the median of FT4 level was 1.4 ng/dL (0.96-1.9) ng/dL. The mean level of Anti-TPO 209.48 IU/mL (SD±588.83) IU/mL. There was a significant correlation between TSH and Anti-TPO (?=0.67,p=0.001,n= 31).
CONCLUSION: There was a very strong correlation between TSH and Anti-TPO in children with T1DM at Dr. Soetomo Academic Hospital.