Meita Dhamayanti, Lani Gumilang, Faisal
BACKGROUND. Maternal vitamin D deficiency during pregnancy may have persistent adverse effects on childhood growth and development. Evidence has accumulated for the association between low vitamin D serum concentrations and mental health disorders in both children and adults. The aim of this study was to analyze associations between 25?hydroxyvitamin D (25(OH)D) status during pregnancy and at cord blood with infant mental-emotional status. METHODS. A prospective cohort of 139 mothers–off spring pairs in Waled and Sukabumi district, West Java, Indonesia, enrolled during the period of July 2016-April 2018. The 25(OH)D was measured at 10-12 weeks gestational age and at birth, as categorized into deficient <20 ng/ml and non deficient (?20 ng/ml) The infant mental-emotional status was assessed by the Age and Stage Questionnaire Socio-Emotional (ASQ-SE) at 12 month of age as categorized into normal and suspected abnormal. Data on vitamin D and mental-emotional status were analyzed with linear regression. RESULTS. Vitamin D deficiency was found in the majority of pregnant mothers (81%) and newborns (80%). The mean Vitamin D levels of maternal and newborn were 17.516+/-7.255 ng/ml and 16.213 +/- 6.146 ng/ml, respectively. The mental-emotional status of the offsprings showed suspicious abnormal in 22.3% Maternal serum vitamin D was significant associated with mental-emotional status of the offspring’s (? = 0.186, p = 0.050, 95% confidence interval (CI) [0.000, 0.251]), meanwhile fetal vitamin D was not CONCLUSION. Maternal 25(OH)D status during pregnancy is associated with mental-emotional status of the infant at 12 months of age