BACKGROUND : In 2016, the case fatality rate for dengue infection in malinau district is 1.1 % (highest in North Kalimantan Province). Circulatory failure was found in dengue haemorrhagic fever grade III and IV mainly due to increment of vascular permeability. Intravenous fluid therapy was given whether for resuscitation and maintenance post resuscitation to replace intravascular fluid loss. Colloid was given for resuscitation but not commonly used to be continued after resuscitation.
The study aims to evaluate clinical outcome of colloid mixed with crystalloid as post-resuscitation fluid.
METHODS: This was a cohort retrospective study. Data were collected from medical record of patients diagnosed with dengue haemorrhagic fever grade III and IV from August 2018 to January 2019. Subjects with hematology problem, previous cardiac, lung, or kidney abnormalities, and referred patients were excluded. Subjects were divided into two groups based on wether colloid mixed with crystalloid or crystalloid only to as continue fluid therapy post resuscitation. We analyze the incidence of recurrent shock, amount of intravenous fluids and length of stay.
RESULTS: There were no significant differences in subject’s basic characteristics, such as age, sex, and nutritional state. There were 18 subjects due to colloid group and 7 subjects to non-colloid group. We found 4 subjects (16%) from colloid group that had recurrent shock but no one from crystalloid group(p=0.294). Length of stay mean of the colloid vs non-colloid group were 3.89 days vs 4.29 days respectively(p=0.59). The mean of total intravenous therapy in colloid group were 39.9 ml/kg/day, and in non- administration colloid group were 45 ml/kg/day(p=0.416).
CONCLUSION: We found no significant differences between the use of colloid mixed crystalloid vs crystalloid only as post-resuscitation fluid in children with DHF grade III and IV.