Background: Typhoid fever is a major health problem in developing countries, with clinical manifestations varying from mild to severe. Variations of antibiotic therapy for typhoid fever patients depend on existing signs and symptoms. An overview of antibiotic response can guide the physician to select the right antibiotic. Objective: To know antibiotic response (chloramphenicol, ampicillin, ceftriaxone, cefotaxime, and ciprofloxacin) given to pediatric patients with typhoid fever. Method: This is a retrospective descriptive study based on 97 medical record data of pediatric patients diagnosed with typhoid fever (0–18 years) from January 1, 2016 to December 31, 2018. Characteristics of the samples obtained from existing signs and symptoms. The antibiotic response based on fever resolution with the first antibiotics administration, and second antibiotics administration, if the fever didn’t resolve.
Results: Mostly manifestations typhoid fever in pediatric patients at Hasan Sadikin Hospital are fever (100%), nausea (52%), diarrhea (48%), abdominal discomfort (35,7%), obstipation (25,5%), and hepatomegaly (24,5%). The antibiotics given in Hasan Sadikin Hospital were chloramphenicol orally, ampicillin, ceftriaxone, cefotaxime, and ciprofloxacin intravenously. After the first antibiotic administration, fever resolved at a mean of 2.66 days in 88 (91%) patients. In 9 (9%) patients whose did not resolve with the first antibiotic, fever resolve at a mean of 3.2 days using the second antibiotic. Conclusion. Common manifestations of
typhoid fever in children who came to Hasan Sadikin Hospital were fever, nausea, and diarrhea. Pediatric patients with typhoid fever still responded well to the administration of first antibiotics.