OBJECTIVE: Neuropsychiatry systemic lupus erythematosus (NP-SLE) is one of the most severe types of SLE. Thirty eight percent SLE patients had NP-SLE manifestation, in which 55% the precence of NP-SLE occurred within one year after diagnosis. We aimed to describe clinical manifestation and onset of NP-SLE in pediatric patients in Dr. Kariadi Hospital.
METHOD: We reviewed data retrospectively. There were 23 NP-SLE patients at Dr. Kariadi Hospital from 2016-2018. We evaluated nutrition status, corticosteroids and another immunosupresan treatment, onset of NP-SLE. We adopted criteria NP-SLE by the American College of Rheumatology (ACR). Data were analysed by descriptive.
RESULT: Twenty three out of 72 (31.9%) cases were NP-SLE patients. Ratio male : female = 1: 22. The most NP-SLE patient had well nourished (69 %) and one was classified as severely malnourished. The mean age of NP-SLE patient was 13,7 (SD 2,1) years old. The duration of SLE developing into NP-SLE starts from 3 to 24 months, with six months as median. Thirteen out of 23 cases received corticosteroids alone, 9 cases combined with CPA, and one with MMF. The most common of NP SLE clinical manifestation were seizures (34,8 %), anxiety disorders (21,7%), headache (17,4%), psychosis (13 %) and cognitive dysfunction (8,7%).
CONCLUSION: The most characteristics of NP-SLE patients in this study were seizures. The duration of SLE will develop into NP-SLE was found in three month.