Background Patent ductus arteriosus (PDA) is one of the most common non cyanotic congenital heart diseases (CHD) in children. Many of them experience malnutrition as a complication that results in high morbidity and mortality. Corrective intervention may improve the hemodynamics status and developmental growth.
Objective To determine weight gain in children with PDA before and 1, 3, and 6 months after transcatheter closure.
Methods We conduct a retrospective study of children 2 years of age or below with PDA at Hasan Sadikin Hospital during 2016 until March 2019. Weight gain were determined as body weight at the time of follow up on 1, 3, and 6 months after transcatheter closure or first visit subtracted by body weight at the time of closure or first visit as control. Children who had no complete data on follow up were excluded. Paired and independent t-test or suitable non parametric test were used for statistical analysis.
Results From the data registry of PDA patients we found 186 subjects fulfilled the criteria to be included in the study, of whom 41(22%) underwent PDA closure. Median age was 9,5 months(range 1-24 months), boys were 76(40,9%) and girls 110(59,1%). Twenty four visits were available at 1 and 3 months and 14 visits at 6 months of follow up in closure groups, and all show significantly increase of body weight with mean increment: 0,37(95%CI:0,08- 0,65;p=0,014), 1,19(95 CI:0,75-1,63;p<0,0001) and 1,94(95%CI:1,1038-2,78;p<0,0001) respectively, however, z-score did not significantly increased. Weight gain at 3 months after
PDA closure showed significantly higher compared with non PDA closure (1,19±1,04 vs 0,55±1,12;p=0,033).
Conclusion PDA closure by transcatheter in children 2 years of age or below resulted in increased of body weight at 1, 3, and 6 months after closure and significantly higher weight gain at 3 months after closure compared with non PDA closure.