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Ref Number = PITIKA-ASPR0410
CORRELATION BETWEEN UPPER RESPIRATORY TRACT INFECTION IN CLINICAL MANIFESTATION OF HENOCH SCHONLEIN PURPURA IN CHILDREN
Merlin Kodir, Raynald O. Takumansang, Diane Sondakh 
Objective : Henoch-Schönlein Purpura (HSP) is a small-sized blood vessel vasculitis due to IgA-mediated inflammation characterized by leukocytoclastic angiitis and predominant cutaneous involvement. Upper respiratory tract Infection (URTI) is found in at least 50% of children with HSP. The objective of this study is to determine the correlation between Henoch-Schönlein Purpura (HSP) who had upper respiratory tract infection (URTI) in clinical manifestation of children.                                                                                                           Methods : This is a hospital based on descriptive, cross-sectional study during December 2008 through December 2018 at Prof. Dr. R. D. Kandou general hospital including 50 children with aged between 3-17 years old with HSP. Children with primary cutaneous vasculitis were classified as having HSP according to European League Against Rheumatism (EULAR). URTI were considered as precipitating event assessed a week prior to the onset of vasculitis. The data was collected from the Prof. Dr. R. D. Kandou general hospital medical record database.   Result : Out of 50 patients with Henoch Schonlein Purpura (25 boys and 25 girls), the mean aged was 9.4 ± 3.08 year. A URTI occured in 54% children with HSP versus 46% without URTI. The children with URTI had higher frequency of abdominal pain 70% (p=0.003), hematuria 66% (p=0.015) proteinuria 37% (p=0.01), arthralgia 18% (p=0.065). Statiscal analysis correlation between the two variables was significance with p=0.021 (OR 2.39, Cl 95% ; p<0.05)                                                                                                                            Conclusion : HSP with URTI with three times higher than without URTI. In clinical manifestation, HSP with a history of URTI seemed to have higher prevalence of kidney complication and gastrointestinal disorders.
Keywords: Upper respiratory tract infection, clinical manifestation, correlation, henoch schonlein purpura, children
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