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Ref Number = PITIKA-ASPR0411
THE ROLE OF BRAIN NATRIURETIC PEPTIDE AS A MARKER FOR HEART FAILURE IN PATIENTS WITH ACYANOTIC CONGENITAL HEART DISEASE LEFT TO RIGHT SHUNT USING SYSTOLIC EJECTION FRACTION
Inayah Djabir, Aizah Lawang, Dasril Daud
OBJECTIVE : Congenital Heart Disease (CHD) is the most common heart disease in children. This study aims to evaluate the role of BNP levels as a marker of heart failure in patients with acyanotic congenital heart disease left to right shunt using systolic ejection fraction.
METHOD : This research is a cross sectional study, from Desember 2017-July 2018, at the Cardiology Division of the Department of Child Health Dr. Wahidin Sudirohusodo Hospital. Subjects divided into 2 groups, heart failure and without heart failure, then each was evaluated for age, sex, nutritional status,and BNP levels. Data were analyzed using SPSS 23, bivariately by Chi-square  and Mann whitney analysis.
RESULT: From a total of 60 subjects, heart failure was noted in 50% and without heart failure in 50%. The results of the bivariate analysis showed a significant difference  in elevated BNP levels in patients with heart failure compared than those without heart failure with p=0,00 (p<0,01) (OR = 95,2  95%CI  10,928-830,856), sensitivity 96,7%, specificity 76,7%, possitive predictive value 80,6%, negative predictive value 95,8%.
CONCLUSION: In our study, there is significant correlation between BNP levels and heart failure.  The increased BNP levels can be valuable for early screening of patients with higher risk of heart failure.
Keywords: Acyanotic Congenital Heart Disease, left to right shunt, Brain natriuretic peptide (BNP), heart failure, ejection fraction
Disclaimer: The Views and opinions expressed in the articles are of the authors and not of the journal.
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