OBJECTIVE:  Evidence based medicine (EBM) plays a crucial role as a tool that helps integrate research evidence into clinical practice. However, few reports have yet to examine its application in daily practice among physicians. The aim of this study was to assess the attitudes towards and knowledge of EBM practice among pediatric residents of Sam Ratulangi University, Manado.  
METHODS: A cross-sectional, self-administered anonymous questionnaire was distributed to 72 residents at Child Health Department of Sam Ratulangi University Hospital in Manado, Indonesia. 
RESULTS: Seventy two residents with level of competence junior, middle, and senior included to this study. Forty five women (63%) participated with mean age 31+ 0,7 old years with level of competence junior 32 residents (44,4%), middle 19 residents (26,4%) and senior 21 residents (29,2%). Seventy five percent of respondents understood the basic terminology of EBM, 17% could explain the terminology used in EBM to others and 25% indicated they would like to understand the terminology more. Eighty percent admitted having a good understanding of EBM basic skills. There is a significant relationship in level of competence with good understanding of EBM skill, with p value <0.001. Ninety two percents indicated having read EBM sources mostly Pubmed or medline journal, but only 7.9% indicated that they use these sources in clinical decision making. 
CONCLUSIONS: In general, respondents positively welcomed EBM, and moderately understood and knew basic EBM skill but only a few that applied it for clinical decision making.