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Ref Number = PITIKA-ASPR0429
EFFECT OF PARAPROBIOTIC ON DEFECATION FREQUENCY AND STOOL QUALITY OF INDONESIAN ELEMENTARY SCHOOL CHILDREN: A DOUBLE BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL
Denta Kurniawan, Lestari Lily, Helmyati Siti, Juffrie Muhammad
OBJECTIVES: This study is aimed to determine effect of para-probiotic consumption on defecation frequency and stool quality of children. 
METHODS: This research was a double blind, randomized, placebo controlled trial that evaluate the effects of fermented milk beverage that contains paraprobiotic consumption on defecation frequency and feces quality. The trial was conducted with 87 subjects were recruited from elementary schools in Kulonprogo Distric, Yogyakarta and divided into 2 groups. There were placebo group that received 125 ml of UHT milk and treatment group that received 125 ml of UHT milk + paraprobiotic 5 x 10^10 CFU/day. The subjects had to consume 1 pack of milk every day for 90 consecutive days. Before and after intervention, several data were collected i.e sign and symptoms of constipation according to Rome III criteria and feces quality according to Bristol stool chart. Chi-square analysis will be done to compare statistically significant differences of the relative risk ratio between the baseline and follow-up data as well as placebo group with intervention group. 
RESULT: This is the preliminary descriptive analysis of follow up results. From 87 eligible subjects, 78 successfully completed the follow up. Of all subjects, 18 subjects (23,68%) fulfilled the Rome criteria of functional constipation prior to the paraprobiotic intervention, compared to 4 subjects (5.26%) after the intervention, irrespective of the intervention group. For quality of the stool, 21.05% were hard stool according to Bristol stool chart prior to the intervention, compared to 18.42% hard stool after the intervention.
CONCLUSION: The result can be analyzed and concluded after the blinding is revealed at the end of June 2019. 
Keywords: pediatric residency, competency
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