OBJECTIVE: The study aimed to investigate the effect of the probiotics in reducing C-Reactive Protein (CRP) levels in adolescents with obesity. 
METHOD: The study was a double-blind placebo-controlled trial including 44 adolescents with obesity randomized to 5 strains probiotics (Streptococcus thermophilus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum) 1,25x109 or placebo daily for 8 weeks.
RESULT: There were no differences in age, sex, any anthropometric measures (weight, height, body mass index) and nutritions status (calorie, proteins, fat, carbohydrate) at baseline between the probiotic and placebo groups. The levels of C-Reactive Protein (CRP) from baseline to 8-weeks intervention were comparable. The difference in levels C-Reactive Protein (CRP) from baseline -0,2 (1,67) to 8-weeks intervention 0,3 (1,22) between the probiotic and placebo groups was significantly different (p = 0,007). There was significantly different of probiotic intervention in reducing C-Reactive Protein (CRP) levels -1,4 mg/L (95% CI: -2,4 to -0,43) (p = 0,006).
CONCLUSION: Probiotic intervention effective in reducing C-Reactive Protein (CRP) levels in adolescents with obesity