INTRODUCTION: Dengue hemorrhagic fever (DHF) is a public health problem characterized by fever and bleeding. Early increases in D-dimer levels in DHF indicate that Disseminated Intravascular Coagulation (KID) and activation of the fibrinolysis system occur earlier, before the occurrence of bleeding manifestations. The aim of this study was to assess D-dimer levels in patients with dengue shock syndrom  and Dengue Hemorrhagic Fever.
METHODS: A cross sectional study in the Department of Child Health RSUP Dr. Wahidin Sudirohusodo Makassar from January 2016 to December 2018. A total of 70 DHF patients were included in this study. The diagnosis of DHF is using WHO criteria. Blood samples collected at first admission.
RESULT: D-dimer levels increased significantly in DSS, with the cut-off point of D-dimer ?1.4 µg/ml as the optimal separator between DSS and DHF obtained through ROC having a value of p = 0,000, sensitivity 94,3%, specificity 65,7%, NPP 73,3%, NPN 92%, Area Under Curve (AUC) 0.800 and OR 31,625; 95% CI (6,457-154,895).
CONCLUSION: D-dimer levels has good validity in determining the occurrence of shock in DHF.