Background. The increased incidence of epilepsy affects the use of more valproic acid and for a longer period of time. This study aimed to determine the effect of valproic acid on SGOT and SGPT levels in pediatric apilepsy patients. 
Method. The study was a retrospective cohort and was conducted from August through October 2018 in the Pediatric Neurology Division of Dr. Wahidin Sudirohusodo Hospital (2 patients with Epilepsy fulfilled the inclusion and exclusion criteria. The subjects were divided into two groups, aged > 2 years old, and underwent Epilepsy treatment with Valproic Acid for 6 months. The data were analyzed using Friedman test. Mann-Whidney test and assisted by SPSS-23. 
Results. The research indicated that the two groups showed no adverse effect on SGOT and SGPT levels. The p value of SGOT aged ?2 years old was p=0,03 and those aged > 2 years old was p=0.894, while the p value of SGPT aged ? 2 years old was p=0.208 and those aged > 2 years old p=0.312.
Conclusion. The side effects were not found in both groups during the 6 months treatment in both groups at the initial month the value of SGOT showed the value of was p=0.002, at the third month it was p=0.013, at the sixth month it was p= 0.639, while the SGPT showed that at the beginning the value of p=0.10, at the third month p=0.007, and at the sixth month p=0 001.