OBJECTIVE.Autism spectrum disorder (ASD) manifests in early childhood and is characterized by qualitative abnormalities in social interactions, markedly abberant communication skills, and restricted repetitive behaviors, interests, and activities (RRBs). ASDs begin in childhood and tend to persist into adolescence and adulthood. In most cases the conditions are apparent during the 5 years of life. It is estimated that worldwide 1 in 160 children has ASD. Based on epidemiological studies conducted over the past 50 years, the prevalence of ASD appears to be increasing globally. The established therapies for autistic disorder are nonpharmacologic. These therapies may include behavioral, educational and psychological treatment. Medication may be effective in the treatment of comorbid disorders, including self-injurious behaviors and movement disorders. Recent evidence indicated that treatment with several antipsychotic could reduce irritability and behavioral symptom in autistic children. The atypical antipsychotic agents, risperidone, have been approved by FDA for irritability associated with autistic disorder. 
CASE.Reporting a case of a 5-year-old boy with autism spectrum disorder (ASD) and irritability treated with risperidone at pediatric clinic at Jayapura, Papua
A 5-year-old male child came to the clinic with diagnose autism spectrum disorder (ASD) with there were hyperactivity, social relationships vary from mild impairment to almost complete lack of interaction. He was treated with Risperidone 2x0,5 mg for the behavior. His behavior includes restricted repetitive, lack of eye contact and communication skill. 2 weeks after treated with risperidone 2x0,5 mg there are some improvements in child’s behavior. The patient still consumes risperidone for a month and show some good improvements.
CONCLUSION.The using of risperidone in this case proves the decreasing of irritability associated with autistic disorder in this child. Except in emergencies, patients, parents, guardians, and surrogates must be aware of the diagnostic and treatment possibilities and must provide permission for possible intervention.