OBJECTIVE: In developing country, obesity remains a public health problem with rapidly increased prevalence. Chronic low-grade Inflammation plays a key role in pathophysiology of obesity. Blood count values and ratios recently used as inflammatory markers of diseases. We hypothesized these parameters able to determine chronic inflammation severity in obese children.
METHOD: We conduct an observational analytic study in obese children 14-18 years at senior high school in Manado, from July to September 2018. We excluded patients with congenital anomalies, autoimmune diseases, history of asthma, and malignancy. Analysis of the relationship of obesity with red blood cell distribution width(RDW), neutrophil-to-lymphocyte ratio(NLR), mean platelet volume(MPV), platelet distribution width(PDW), and platelet-to-lymphocyte ratio(PLR) with Pearson correlation. Significance value p<0.05. Data analysis using SPSS 25.
RESULTS: Out of a total of 41 children, 25 (61%) children were male. There was statistically insignificant negative correlation between obesity and MPV (r = 0.006, p = 0.485). There were statistically insignificant positive correlations between obesity and RDW,NLR,PDW,and PLR (r = 0.139, p = 0.192; r = 0.155, p = 0.166; r = 0.02, p 0.45 and r = 0.146, p = 0.181, respectively).
CONCLUSION: RDW,NLR,MPV,PDW,and PLR did not show chronic inflammation severity in obese children.