Background: Baclofen is widely used to treat spasticity . Although central nervous system depression is the most commonly described manifestation of baclofen toxicity , cardiovascular effects including bradycardia and conduction abnormalities have been reported. Case A: 12-year-old boy with spastic quadriplegic cerebral palsy (GMFCS V) on multiple antispastic medications (oral baclofen, benzhexol/trihexyphenidyl, and Syndopa) was found to have severe bradycardia and poor peripheral perfusion during routine admission for nasogastric (NG) tube change. Blood pressure was noted to be around 50th centile. There was no history of recent infection, dehydration, or medication dose change. Initial ECG showed sinus arrhythmia. Laboratory investigations were normal. Baclofen was omitted and within 6 to 8 hours heart rate returned to baseline with improved perfusion. Conclusion: Baclofen toxicity or drug sensitivity may present with cardiovascular depression. Early recognition and withdrawal of the drug can result in rapid clinical improvement.