Introduction: Dengue is an illness with lot of morbidity and mortality . Oxidative stress plays a key role in disease pathogenesis. Therefore, exogenous antioxidants could alleviate disease severity and improve recovery . This study aims to explore the effects of vitamin E in the outcome of Dengue Fever. Methods: A cohort study was conducted at the University Paediatric Unit(treatment group) and a General paediatric ward(control group) at a tertiary care hospital for children in Sri Lanka. 35 children (5-14 years) with clinically suspected dengue infection within 84 h of onset of fever. The treatment group(n=27), received an age appropriate dose of vitamin E within 24 hours of admission. Controlled group(n=8) were given standard care. Haematological and biochemical parameters were assessed regularly . Serum Trolox equivalent antioxidant capacity(TEAC) was analysed using the ABTS assay . Results: Progression to DHF and duration of leaking phase was lower in the treatment group (2 days, IQR 2-5 Days) compared to controls (3, IQR 3-5 days). Serum TEAC in the treatment group improved and was maintained during illness. Their serum uric acid also improved following supplementation, indicating its role as compensatory antioxidant. In the vitamin E group, serum TEAC showed non-significant positive correlation with uric acid (r = 0.5238, p=0.1966), WBC count (r = 0.5714, p=0.1511), calcium (r =0.3810,p=0.3599), and negative correlation with albumin (r= - 0.6190,p=0.5364). Conclusion: Preliminary data shows that vitamin E supplementation has a beneficial impact on the outcome of dengue infection. Future studies with larger sample size should be carried out to validate the observed associations.