Background: Family resilience helps families cope with adversity . Neonates in closed NICU experience parent-nfant separation, leading to parental role difficulties, negative emotions,financial burden, and impaired family functioning. Research on family resilience in this population remains limited. Objective: This study explores the profiles and influencing factors of family resilience among hospitalized neonate families to support targeted interventions. Methods: A cross-sectional study with convenience sampling was conducted in two tertiary Grade A maternal and child health hospitals in Sichuan Province from Dec 2023 to May 2024. 301 parents of hospitalized neonates were surveyed with relevant questionnaires; Mplus 8.3 was used for LPA of family resilience, and SPSS 27 .0 for statistical analyses and multinomial logistic regression to explore influencin factors. Results: The total score of family resilience among families of hospitalized neonates was 54.17±5.04. Three latent profiles were identified: moderate commitment-low control (36.6%), high family resilience (8.6%), and low commitment-low challenge (54.8%). Multinomial logistic regression showed that educational level (high school/technical secondary school or below), monthly per capita family income (