Abstract Ref Number = APCP1059
FLUID STATUS AND BRONCHOPULMONARY DYSPLASIA WITH PATENT DUCTUS ARTERIOSUS IN PRETERM INFANTS
Ferry Liwang,Tommy Gunardi Santoso,M Reza Syahli,Dina Amalia Pratiwi,Octafika Hairlina Ayu Latifa,Toto Wisnu Hendrarto
Assistant Neonatology Working Group Indonesia Pediatric Society Perinatology Department, Harapan Kita Children and Womens Hospital
Background : Bronchopulmonary Dysplasia (BPD) is the most common respiratory complication experienced by preterm infants. Patent Ductus Arteriosus (PDA), as a mechanism for BPD, causes excess fluid and protein in the lung which results in pulmonary fluid overload. Fluid restriction is most frequently used as part of the management of preterm infants with BPD. The objective of this study is to analyze the correlation between excessive fluid in BPD patients with and without PDA.
Material : An analytical study was conducted in a retrospective cohort, reviewed 208 preterm infants that were born of BPD from medical record of Neonatal Intensive Care Unit, Harapan Kita Children and Women’s Hospital, Jakarta, during the period of May 2016 until May 2018. In this study, fluid overload within the first 7 days of hospitalization and 7-14 days of hospitalization are defined as having a total volume (TV) of 150 mL/kgBW/24 hours and 175 mL/kgBW/24 hours, respectively. Bivariate analysis was performed to assess the correlation between excessive fluid administration in BPD patients with and without PDA.
Results : Mean gestational age between BPD with and without PDA groups was 29.17 ± 3.70 weeks and 31.15 ± 2.72 weeks, respectively. Mean birth weight of those groups was 1203.28 ± 570.72 gram and 1508.26 ± 542.25 gram. Of 208 preterm infants, 18 (8.65%) were BPD patients with PDA. Excessive fluid did not show a significant correlation between the two groups for the first 7 days of hospitalization. However, a significant correlation was observed in BPD patient without PDA (p<0.005) in the period of 7-14 days of hospitalization.
Conclusions : This study demonstrated that fluid restriction was more recommended for BPD patients with PDA than without PDA, especially in the period of 7-14 days of hospitalization. An overloaded fluid administered for preterm infants should be avoided as it increases the risk of developing BPD.
Keywords: bronchopulmonary dysplasia fluid overload patent ductus arteriosus preterm infants