Abstract Ref Number = APCP1170
Correlation of cord blood IGF-1 level, fetal weight gain during 3rd trimester and birth weight
Bob Kevin Pardede,Agustini Utari,JC Susanto,Rina Pratiwi,Maria Mexitalia,Julian Dewantiningrum
Department of pediatrics faculty of medicine Diponegoro University Department of Obstetric and Gynecology faculty of medicine Diponegoro University
Background : Insulin Growth Factor 1 (IGF-1) plays an important role in somatic growth regulation and organ development in early fetal life. There is strong evidence that IGF-1 play a central role in controlling growth in response to nutritional and metabolic signals.
Material : This is a cohort study of 52 mothers and their offsprings (32 male and 20 female newborn) who enrolled from 9 primary health care and 5 hospitals in Semarang in 2017-2018. IGF-1 serum was taken from umbilical cord, Estimated Fetal Weight (EFW) was measured by ultrasound and plotted to WHO Fetal Growth Chart 2017. It was interpreted with faltering of weight gain (Group I, the percentile was decreased more than 2 major percentiles), normal weight gain (Group II was defined as the same percentile), and significant weight gain (Group III, was increased more than 2 major percentile). Maternal intake during third semester was measured by food recall. Statistical analysis was done using Pearson correlation and One way Anova.
Results : The mean IGF-1 level in cord blood was 91.53 ng/ml (SD 32.98). The mean IGF-1 level at significant weight gain group was 134.8 ng/ml (SD 33.9), normal weight gain group was 86.2 ng/ml (SD 28.9), and faltering of weight gain group was 82.9 ng/ml (SD 25.9). IGF-1 level was correlated with birthweight (r= 0.456; p= 0.001) and fetal weight gain (r=0.446; p= 0.007). There were no correlation between energy and protein intake during pregnancy with fetal weight gain, birth length, and IGF-1 level.
Conclusions : There were significant correlation between cord blood IGF-1 level with fetal weight gain and birth weight. Higher cord blood IGF-1 levels were found to be correlated with large birth weight in newborn.
Keywords: Cord blood IGF-1 Fetal weight gain Maternal protein intake