Abstract Ref Number = APCP920
INFECTIOUS COMPLICATION IN CHILHOOD WITH ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH INDONESIAN ACUTE LYMPHOBLASTIC LEUKEMIA CHEMOTHERAPY 2013
Alexander Josediputra,Andi Cahyadi,Maria Shanty,Mia Ratwita,IDG Ugrasena,Bambang Permono
Department of Child Health Faculty of Medicine Universitas Airlangga Dr Soetomo Hospital Surabaya Indonesia
Background : Infection is a major complication in pediatric patients with acute lymphoblastic leukemia during chemotherapy. The frequency of treatment related mortality in ALL trials is reported to be 2%–4%, mostly due to infections. The aim of this study is to describe and compare the infectious complication between ALL High Risk (HR) and ALL Standard Risk (SR) of children who received ALL chemotherapy.
Material : We studied cross sectionally of 631 ALL patients in all phase chemotherapy under 18 years old who treated with Indonesian ALL chemotherapy protocol 2013 at DR. Soetomo hospital from June 2017 until December 2017. We classified the patients into two groups ALL SR and HR. and evaluated clinically documented infections. We analyzed the characteristic for infection with Chi-square (?=0.05).
Results : There were 65 out of 631 (10.3%) patients with clinically documented infections (50.8% ALL SR, 49.2% ALL SR). There were 5 (7.6%) sepsis, 3 (60.0%) of them were in induction phase. Twenty-three (35.0%) pneumonia infection, 8 (34.8%) were in consolidation phase. Fourteen (21.5%) diarrhea, 6 (42.8%) was in maintenance phase. Two (3%) amoebiasis, 2 (3.0%) tinea cruris, 2 (2.8%) candidiasis, 4 (6.2%) cellulitis, 4 (6.2%) gingivitis, 4 (6.2%) candidiasis, and 8.3% other infections. Sepsis was more common in ALL HR (p=0.024), diarrhea was more common in ALL SR (p=0.03), and age more than 5 years was more common in ALL HR (p=0.001)
Conclusions : Pneumonia is a major complication in pediatric acute lymphoblastic leukemia during consolidation phase in Indonesian ALL chemotherapy protocol 2013. Sepsis is more common in ALL HR and diarrhea is more common in ALL SR.
Keywords: acute lymphoblastic leukemia child, infection risk factors