Background: Cervical lymphadenopathy is an enlargement of lymph node > 1 cm in the cervical region. Etiology varies, in developed countries 70% are reactive lymphadenitis, whereas in developing countries 56.67% are tuberculosis infections. No studies in Indonesia about this topic. Aim: To know the profile children with cervical lymphadenopathy in Outpatient Clinic, RSCM Kiara, Jakarta. Method: Descriptive cross-sectional design on 6126 subjects aged 1 month – 18 years, found 93 subjects experiencing cervical lymphadenopathy. These subjects underwent interviews and the diagnosis process observed. Result: Prevalence of cervical lymphadenopathy is 1.5%. From 93 subject, 70% cervical lymphadenopathy is not the main complaint. The most often constitutional symptoms are fever (43%), malaise (37.6%) and weight loss (36.5%). Most of the lymphadenopathy are 1.1-2 cm in size, multiple, location in anterior, 25.8% felt to be conglomerated and fixed, only 2.1% are tenderness. Most common medical diagnoses were tuberculosis infections (35.5%), malignancies (20.5%) and only 2.1% are acute cervical lymphadenitis. Biopsy was done to 28 subject (FNAB/open biopsy) 35,7% are tuberculosis infections, 25% are malignancies and 14,2% are non-specific chronic inflammation. Conclusion: Prevalence of cervical lymphadenopathy in children is 1,5% and the most often medical diagnose and biopsy profile are tuberculous infection.