Beatrice Koesmarsono, Jeanette Manoppo
OBJECTIVE : In recent years, there has been increasing appreciation on nutritional imbalances, both on obesity and malnutrition that affect our immune response, especially in mucosal gut immunity. Alterations in cellular metabolism influence immune cell function. Fecal calprotectin (FC) is a biomarker protein that works as an innate immune system in the mucosal gut. This study aimed to evaluate the association between nutritional status and mucosal gut immune system in elementary school using FC concentration. METHOD : Healthy children aged 6-12 years in Elementary School in Manado were enrolled in this study. The subjects were consecutively recruited from February to April 2019. Children’s stool samples were collected, analyzed with FC concentration. The children's weights and lengths were measured. Nutritional status was based on Body Mass Index (BMI). Data were analyzed by Gamma correlation using SPSS version 25 software. RESULT : In total 38 children were recruited; 22 boys (57.9%) and 16 girls (42.1%). According to BMI, the subjects were divided into 4 groups: 3 children underweight (7.9%), 23 children normal (60.5%), 6 children overweight (15.8%) and 6 children obesity (15.8%). From 38 children, only 8 children whom FC concentration were high (> 50µg/g); 6 children were normal and 2 children were overweight. There were no correlation found between nutritional status and FC concentration (rG = -0.108; p = 0.713). CONCLUSION : Our research found that there were no correlation found between nutritional status and mucosal gut immune system.