Vetria Sekar Damayanti, Farida Niken Astari N.H., Andita Kurnia Siwi, Widiarahma Hapsari
Background : Electroencephalography (EEG) recording requires patient’s cooperation to sleep quietly, but in uncooperative children, mild sedation may help the process of EEG recording. Chlorpromazine is available in intramuscular injection and oral regiments. Intramuscular chlorpromazine gives rapid onset and long sedative duration. Chloral hydrate, only available in oral regiment, gives moderate onset and long sedative duration. In order to provide the best and safe sedation and to minimize invasive procedure and traumatic effect to the children, we conduct this study to compare sedative effect between oral chlorpromazine and oral chloral hydrate. Objective : to compare sedative effect between oral chlorpromazine 1 mg/kg BW and chloral hydrate 25 mg/kg BW in children undergo electroencephalography in Academic Hospital Gadjah Mada University Material and method : This study was conducted in Academic Hospital Gadjah Mada University, from 01 August to 30 November 2018, with double blind randomized control trial design. Subjects and investigators were blinded to the treatment. Forty children aged 0-18 years who met inclusion criteria were randomized into two groups : group A with oral chlorpromazine 1 mg/kg BW and group B with oral chloral hydrate 25 mg/kg BW. The sedative effects were observed and measured using University Of Michigan Sedation Scale (UMSS) score every 5 minute until 30th minute after drugs administration. Statistical analysis was conducted with Mann-Whitney test to compare UMSS score between study groups. Results : The UMSS score showed significant statistic difference between two groups in the 10th minute (p = 0.021) and 20th minute (p = 0.035) after drugs administration. Oral chlorpromazine had higher UMSS score mean in all observation stage after drugs administration. Conclusion : oral chlorpromazine gives better sedative effect than oral chloral hydrate in children undergo electroencephalography.