Abstract Ref Number = APCP891
HEMOSTATIC PARAMETERS IN HYPERLEUKOCYTOSIS LEUKEMIA LYMPHOBLASTIC ACUTE-L1
Nurhudayah Jamaluddin AP,Dasril Daud ,Nadirah Rasyid Ridha ,Setia Budi Salekede ,Martira Maddepungeng ,Burhanuddin Iskandar
Departemen Ilmu Kesehatan Anak FK Universitas Hasanuddin Departemen Ilmu Kesehatan Anak FK UNHAS
Background : The increasing rate of morbidity and mortality in leukemia were commonly found in patients with hyperleukocytosis. Hyperleukocytosis is defined by the white blood cell count (WBC) more than 100.000/mm3, but for the clinical importance it will be treated when WBC is above 50.000/mm3. Hyperleukocytosis is one of oncologic emergencies that need an immediate treatment. This study aimed to assess the differentiation of hemostatic parameters between ALL-L1 with hyperleukocytosis and without hyperleukocytosis.
Material : This cross sectional study were conducted in Dr. Wahidin Sudirohusodo Hospital during November 2016 until April 2017. Seventy-two patients aged 1 month old–18 years old were diagnosed with ALL-L1 based on BMP result. They were divided into two groups; hyperleukocytosis group (31 patients) and without hyperleukocytosis group (41 patients), and then assessed by hemostastic parameters laboratory examination (Platelet, PT, APTT, D-Dimer, and Fibrinogen).
Results : There were no significant difference in platelet count, PT, APTT, D-Dimer and fibrinogen levels between ALL-L1 patients with hyperleukocytosis and without hyperleukocytosis. Mean of platelet count with p value = 0.621, mean PT with p value = 0.429, mean APTT with p value = 0.918, mean D-Dimer with p value = 0.882 and mean fibrinogen with p value = 0.455.
Conclusions : There were no significant difference in hemostatic parameters between ALL-L1 patients with hyperleukocytosis and without hyperleukocytosis.
Keywords: hemostatic parameters ALL-L1 hyperleukocytosis