Abstract Ref Number = APCP924
FREQUENCY AND RISK FACTORS OF THE FORMATION ALLOANTIBODY AND AUTOANTIBODY ERYTHROCYTE ON CHILDREN WITH THALASEMIA IN DR SOETOMO HOSPITAL
Priscilla Harmany,Andi Cahyadi,Maria C Shanty,Mia Ratwita,IDG Ugrasena,Bambang Permono
Departement Of Child Health Faculty Of Medicine Airlangga University Dr Soetomo Hospital Surabaya Indonesia
Background : Thalassemia is an inherited blood related disorder due to absent or reduced production of hemoglobin which needed lifelong transfusion of red blood cells (erythrocytes) to maintain hemoglobin levels, it associated with the formation of autoantibodies and alloantibody erythrocyte. The aim of this study is to describe frecuency and risk factors of the formation alloantibody and autoantibodi erythrocyte on children with thalassemia in Dr. Soetomo Hospital Surabaya.
Material : A retrospective study of 51 cases diagnosed as thalasemia was perform in hematology outpatient clinic Dr. Soetomo Hospital Surabaya from April 2017 to April 2018. The characteristic data were obtained from medical record. Autoantibody was evaluated by incubating recipient erytrosite by reacting polyspecific antihuman globulin (anti IgG + C3d) directly antiglobulin test (DAT). Alloantibodies are used to evaluate the presence of specific antibodies present in plasma recipients when taking blood samples. Testing with commercial cell panel kit as applicable at Blood Bank Installation, RSUD Dr. Soetomo Surabaya. Statistical analysis using chi square with test with significant p<0.05.
Results : There were 51 patient included in this study with mean age 102 (19.9) months, 51% were female which 5.4% give positive result of alloantibody. The formation of autoantibodies and alloantibodies erythrocyte were 3 (5.9%). There were no significant difference between autoantibodies vs alloantibodies with gender (p=0.125 vs p=0.11), hepatomegaly (p=0.338 vs p=0.662), splenomegaly (p=0.634 vs p=0.195), type of thalassemia (p=0.575), rhesus type blood (p=0.779), and ABO type blood (p=0.264). The most common alloantibodies were anti-K.
Conclusions : the formation of autoantibodies and alloantibodies erythrocyte in pediatric thalassemia are still rare, but increasing the frequency of transfusion can affected the formation of autoantibodies and alloantibodies in pediatric thalassemia.
Keywords: alloantibody autoantibody thalassemia transfusion