Abstract Ref Number = APCP938
THE CORRELATION OF NEUTROPENIA STATUS WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AT DR SARDJITO GENERAL HOSPITAL
Adiel Christian Saputra,Eva Luchinta,Bambang Ardianto,Eddy Supriyadi,Sri Mulatsih,Sutaryo
FKKMK UGM Department of Child Health Dr Sardjito General Hospital
Background : Acute Lymphoblastic Leukemia (ALL) is the most common cancer of children and remains the leading cause of cancer deaths in children. Neutropenia is one of many features related to depression of bone marrow function. Neutropenia is a reduction in the number of neutrophils in the blood. This study was conducted to identify the correlation of neutropenia status before, on day 8, and at the end of induction phase of Indonesian ALL-2013 Protocol with the remission status in children with ALL at Dr. Sardjito General Hospital.
Material : This is a retrospective study. Absolute neutrophil count (ANC) of 175 patients before, on day 8, and at the end of the induction phase were collected from the medical records of the patients treated with Indonesian ALL-2013 Protocol. ANC<1.000/uL was categorized as neutropenia. Blast <5% on bone marrow aspiration after completing the induction phase was considered as remission. Data were analyzed using Chi-Square and Contingency Coefficient test. The result is considered significant when the p<0,05.
Results : From 175 subjects, 153 were eligible for further analysis. There were 147, 101, and 138 data of ANC before, on day 8, and at the end of the induction phase, respectively. The neutropenia status before and on day 8 the induction phase were not correlated with the remission status of the patient, p=0,098 and p=0,326, respectively. The neutropenia status at the end of the induction phase was correlated with the remission status of the patient (p=0,016), yet it is considered weak (r=0,2).
Conclusions : Neutropenia status in the end of induction phase is correlated with the patient’s remission status at the end of induction yet the correlation is weak. Further study is needed to investigate the impact and the management of neutropenia in childhood ALL.
Keywords: Acute Lymphoblastic Leukemia Neutropenia Remission ALL