Ref Number = PITIKA-ASPR0102
Bethseba B. Pulinggomang, Irene Ratridewi
OBJECTIVE : Cytomegalovirus (CMV) infection is the most common cause of congenital infection and the leading nongenetic cause of sensorineural hearing loss and neurodevelopmental sequelae. The estimated incidence in developing countries is between 1 and 5% of all live births. The clinical spectrum of CMV infection varies widely, and often goes undetected because the majority of infected infants are asymptomatic at birth. The aim of this study was to describe clinical characteristics and laboratory finding of children with CMV.                                                                                                                                METHOD : It is an observational study, using medical records of all the children who admitted in pediatric department of Saiful Anwar Hospital on January 2018 to December 2018 with clinical symptoms such as retinitis, sensorineural hearing loss, CNS abnormalities, cholestasis, and microcephaly. CMV was investigated based on specific markers (antiCMV IgM, CMV polymerase chain reaction in urine).                                                                                                               RESULT : Median age of patients was 1.9 months. Microcephaly was the most common clinical characteristic (28 cases, 53%). Serum anti­CMV IgM was positive in 15 patients (28,8%), and urine CMV PCR was positive in 8 patients. Among these 8 patients, positive serum anti-CMV IgM was found in 5 patients. Cholestasis was the common clinical characteristic in patient with positive anti-CMV IgM. Retinitis, cholestasis and microcephaly were the common clinical characteristic in 8 patients who confirmed CMV infection. There are 6 patients who had the administration of gancyclovir.                                                                                                                       CONCLUSION : Retinitis, cholestasis and microcephaly were the common clinical characteristics in children with CMV infection. 
Keywords: Cytomegalovirus infection, microcephaly, cholestasis
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