OBJECTIVE: Congenital Rubella Syndrome (CRS) is a collection of symptoms of disease caused by infections of the rubella virus in the fetus during pregnancy because the mother has no immunity to the rubella virus. The clinical manifestations of CRS include growth retardation, cardiac defects, cataracts, and hearing impairment. The World Health Organization (WHO) estimates that worldwide over 100,000 babies are born with CRS every year despite the availability of safe and inexpensive vaccines, thus highlighting the need for broader vaccination coverage programs. We aimed to blow up this issue to give more concern from goverment and health care provider. METHOD: The cases was collected retrospective from Medical Record in DR M Djamil Hospital from 2016 - 2018. All of the pediatric patients were examined, suspicious patient with any symptoms were examined and partially confirmed with serologic examination. RESULT: We got 23 cases during 2016-2018 (5 patients in 2016, 8 patients in 2017, and 10 patients in 2018), 18 boys (78%) and 5 girls (22%). With 9 children (40%) have been confirmed serologically. All of pediatric patients experience congenital cataracts. 12 patients (52.1%) had sensorineural hearing loss, 7 patients (30.4%) had a heart defect in the form of PDA 3 children, VSD 2 children, ASD 3 children. In neurologic symptoms we got 43% experience microcephaly. In growth and developmental, 20 patient diagnosed with Global Developmental Delay. CONCLUSION: The CRS cases in the DR M Djamil Hospital during 2016-2018 were 23 cases which caused abnormalities in the eyes, ears, heart, head and others. CRS is congenital infection that can be prevented by vaccines and is an important public health problem both globally and in Indonesia. More researches still need to be done for this issue.