OBJECTIVE: Dengue Hemorrhagic Fever (DHF) has become a health sector problem in Indonesia, as its incidence and the mortality rate escalate over the years. DHF is causing death in children as a result of hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelium dysfunction. Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection. The aim of this study to show the current signs and symptoms of DSS and DHF in Padang city. METHOD: This study used cross-sectional comparative observational design conducted on children with DHF and DSS at DR M Djamil Hospital and four other hospitals. The subjects number is 110 children, confirmed with serologic test. We examined the clinical manifestation and laboratory parameters. Data were collected from July 2016 until June 2018. RESULT: Most cases had secondary immune response, with only 10 clear primary infection. We have 62 patients with DSS and 48 patients with DHF. Mucosal bleeding in DSS was 17 patients (75,8%) with p value 0,001. Abdominal pain in DSS was 47 patients (75,8%) and DHF was 4 patients (8,3%) with p value 0,000. Persistent vomiting in DSS was 40 patients (64,5%) and DHF was 5 patients (10,4%) with p value 0,000. Hepatomegaly in DSS was 50 patients (80,6%) and DHF 8 patients (16,7%) with p value 0,000. And in laboratory result showed significant findings in increasing hematocrit >40% in DSS 54 patients (87,1%) and DHF 30 patients (62,5%) with p value 0,005. Decreasing platelet <50.000/mm3 in DSS 52 patients (83,9%), but in DHF only 5 patients (10,4%) with p value 0,000. (p<0,05 is significant) CONCLUSION: Signs and symptoms are still the best way of diagnosis in dengue infection and laboratory as the confirmation in treating the patients. Knowing and understanding the conditions of our patients can give an excellent outcome.