Fediah Chia Iskandar, I Wayan Bikin Suryawan
Background: Neonatal sepsis is an important cause of mortality and morbidity both in developed and developing countries. Delays in the identification and treatment of neonatal sepsis are among the main contributors to the high mortality. Objective: To determine the risk factors of neonatal sepsis in NICU and perinatology in Wangaya General Regional Denpasar Hospital. Methods: An analytic study with a case control was obtained in Wangaya General Regional Hospital. The subjects were inpatient babies in the Perinatology ward and Neonatal Intensive Care Unit (NICU) and was born in Wangaya Regional Public Hospital, Denpasar city from 01 September 2017 to 30 May 2019. There were 58 sampels that match to the inclusion and exclusion criteria in each group. Consecutive sampling and gender matching were performed for the subjects selection. The data of risk factors and neonatal sepsis were collected from the medical record. Statistical analyses included McNemar and logistic regression using SPSS v21 software with p<0,05. Results: Bivariate statistical analyses results from neonatal sepsis risk factors were p value= 0,000 for intra partum fever, p value= 0,302 for premature ruptures of membranes more than 24 hours, p value= 0,000 for gestational age, p value= 0,000 for APGAR score, and p value= 0,000 for low birth weight. Meanwhile, from multivariate analyses there were significant results for intra partum fever factor, p value= 0,000 (OR = 25,7; CI95% = 5,30 – 124,85), gestational age factor with p value= 0,000 (OR = 11,4; CI95% = 2,61 – 49,76), APGAR score factor with p value= 0,000, (OR = 6,9; CI95% = 2,05 - 23,41), and low birth weight (p = 0,000, OR = 1,8; CI95% = 0,52 – 6,78). Conclusion: History of intra partum fever, prematurity, APGAR lower than 7, and low birth weight have significant association with neonatal sepsis in Wangaya General Regional Hospital.