Pamela Aprilia Lumentut, Ronny Rahardja, Johnny Rompis, Rocky Wilar
OBJECTIVE: Neonatal sepsis remains one of the major causes of morbidity and mortality among both term and preterm infants. Rasio number of neutrophils - lymphocytes (RNL) as measured parameters are easy to demonstrate the degree of inflammation and sepsis To analyze the role of neutrophil ratio - lymphocytes in response rate in the treatment of early-onset neonatal sepsis. METHOD: Population in this study were treated neonates in the NICU-Sub Division of Neonatology, Department of Pediatrics FK UNSRAT, Prof. Dr. R D Kandou hospital with suspected early-onset neonatal sepsis in July 2018 - August 2018, Samples were taken from all newborns with suspected neonatal sepsis. How sampling is consecutive sampling is obtained based on the sequence of study subjects was admitted (when signed in intensive care). RESULTS: Association ratio of neutrophils - lymphocytes with neonatal sepsis used logistic regression analysis, the results of this test states that a highly significant correlation between RNL with a chance of early-onset neonatal sepsis (p = 0.006) .Role of early onset neonatal sepsis therapy in patients tested with the paired t test, for n > 30 The results of this test obtained by value t = 13 654 with p <0.0001 RNL mean scores after treatment with antibiotics for 3 days, then 38 infants experienced clinical improvement response, the average value of RNL has been under the 1.74 cut-off point; whereas only 12 (24%) patients who still have RNL 1.74. CONCLUSION: In this study, a highly significant relationship between the ratio of neutrophils lymphocytes with early-onset neonatal sepsis and treatment response rate against RNL in early onset neonatal sepsis. RNL where the higher the value the higher the possibility of sepsis. Neutrophil lymphocyte ratio can be considered as a biomarker in assessing response to treatment in early onset neonatal sepsis.