Rizky Amrullah Nasution, Dany Hilmanto
Objective: Hyperuricemia theoretically can accelerate chronic kidney disease progression into end stage renal disease. The aim of this study was to determine any correlation between uric acid level and disease severity based on estimated glomerular filtration rate in children with chronic kidney disease. Methods: This study was a cross-sectional study conducted in Hasan Sadikin General Hospital from March to May 2019. Data regarding age, sex, severity of chronic kidney disease, estimated glomerular filtration rate, ureum, creatinine, and uric acid were collected from 38 children with chronic kidney disease treated both in pediatric ward and outpatient clinic. Spearman and Mann-Whitney test were used to determine the bivariate correlation of uric acid level with estimated glomerular filtration rate and severity of the disease. Results: 38 patients were included in this study. The median of estimated glomerular filtration rate was 120 mL/min/1,732. 19 patients had normal uric acid level meanwhile the other 19 patients were classified as hyperuricemia based on age and sex. There was no significant correlation between uric acid level and estimated glomerular filtration rate (r -0,198, p=0,240). Uric acid level also was not significantly correlated with severity of chronic kidney disease (r 0,276, p=0,098). The median of estimated glomerular filtration rate in hyperuricemia group and normal uric acid level group are 83,1 mL/min/1,732 and 150 mL/min/1,732, respectively. Bivariate analysis of this median difference was significant (p<0,05). Conclusion: Uric acid level were not correlated with disease severity based on estimated glomerular filtration rate in children with chronic kidney disease. Somehow, there was significant estimated glomerular filtration rate median difference between normal uric acid group and hyperuricemia group. Further study should be conducted to investigate this finding.