Sindy Amalia Febrianti, Nanan Sekarwana, Dedi Rachmadi, Dany Hilmanto, Ahmedz Widiasta
OBJECTIVE: The aim of this study was to determine the correlation between frequency of cyclophosphamide intravenous administration with nephrotic syndrome resistant steroid remission in children. METHODS: This study was a retrospective cohort study of 58 children with nephrotic syndrome resistant steroid who got intravenous cyclophosphamide as treatment in Hasan Sadikin Hospital during at the period January to December 2018. The data were obtained from medical record. The age, sex, frequency of cyclophosphamide treatment, and patient’s urinalysis data were collected. Chi square and coefficient contingency were used to determine the correlation of age, cyclophosphamide administration and remission incidence. RESULTS: There are 56 children whose diagnosed with resistant steroid nephrotic syndrome in January 2018 to December 2018. There are 36 patients who had remission and 22 patients who had no remission after intravenous cyclophosphamide. We divided age of the patients with remission into four categories, 9 patients were 1-4 years old,12 patients were 5-9 patients,13 patients were 10-14 years old, and 2 patients were 15-18 years old. Frequency of intravenous cyclophosphamide administration had significant correlation with nephrotic syndrome resistant steroid remission in children (contingency coefficient 0.4668;p<0.001). CONCLUSION: The frequency of intravenous cyclophosphamide was correlated with possibility of remission in resistant steroid nephrotic syndrome patient, therefore cyclophosphamide still become a therapeutic option for resistant steroid nephrotic syndrome.