Ref Number = PITIKA-ASPR0408
Tania Putri Ryandini, Reni Ghrahani, Gartika Sapartini, Budi Setiabudiawan
OBJECTIVE : Henoch Schonlein Purpura (HSP) is the most common vasculitis in children and the incidence is increasing. The most common complication of HSP is nephritis. It requires long-term management, decreases quality of life, has high mortality. There is still no standard and validated way of identifying the risk factors for renal involvements. Some laboratory predictive factors of system involvements, such as low lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lyphocyte ratio (PLR) has been previously described. This study to evaluate hematologic parameters of patients with Henoch Schonlein Purpura as predictive factor of renal involvement.
METHOD : All patients newly diagnosed as having HSP were reviewed retrospectively. White blood cell count, hemoglobin, platelet counts, neutrophil and lymphocyte count were evaluated. NLR and PLR were calculated using the results from complete blood count tests.
RESULT. There were 54 children newly diagnosed with Henoch Schonlein Purpura who was hospitalized in Hasan Sadikin General Hospital during 2017-2018. Mean age at diagnosis was    106.09  ± 38.12 months old. Nephritis HSP was found in 16 patients. The C-reactive protein was significantly lower in nephritis HSP patients (p = 0.009). The average NLR and PLR at the time of diagnosis was lower in patients with HSP nephritis than in those HSP without renal involvement (p = 0.265 and 0.564 respectively). No significant difference was found in hemoglobin level, white blood cells count and platelet count of the patients with and without renal involvement.
CONCLUSION : NLR and PLR was found lower in nephritis HSP patients than in non-nephritis. Further study is needed to evaluate NLR and PLR as predictive factor of renal involvement in HSP.
Keywords: Henoch schonlein purpura, NLR, PLR.
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