Isvarani Devana Irawan, Suryadi Nicolaas Napoleon Tatura
OBJECTIVE: Hepatic involvement is one of the well-recognized feature of Dengue Viral Infection (DVI) and it is more commonly happened in children. Coagulation abnormalities have been associated with hepatic dysfunction. This study was conducted to assess correlation between liver function profile and coagulation abnormalities in children with DVI. METHOD: A prospective cross-sectional study was done in pediatric ward of Prof. Dr. R.D. Kandou General Hospital on January 2019. Samples were taken concecutively. Inclusion criteria were children aged 1 months-18 years old with clinical symptoms of dengue and having a positive dengue serologic marker (NS1, IgM, and IgG antidengue). Samples were diagnosed and classified according to WHO 2011 grading of dengue severity. Exclusion criteria was parents who reject to participate in the study. All samples were examined for Aspartate transaminase (AST), Alanine transaminase (ALT), Prothrombin Time (PT), and activated Partial Thromboplastin Time (aPTT). Minimum sample size were 38 with ?=0.05 and power 0.8. Sample characteristics were described and correlation between liver function profile, PT, and aPTT were analyzed using spearman correlation test (significant if p<0.05). RESULT: Forty samples were met the inclusion criteria. Median age was 7.5 (1-16) years old. Median body weight was 25 (9-79) kg. Median of serum AST and ALT was 127 (35-1988) U/L and 53.5 (9-674) U/L, respectively. Whereas median of PT and aPTT was 13.55 (11.7-19.8) seconds and 43.5 (28.20-64.40) seconds. Correlation between each liver function with PT and aPTT were all significant (AST-PT, r=0.411, p=0.004; AST-aPTT, r=0.278, p=0.041; ALT-PT, r=0.408, p=0.004; ALT-aPTT, r=0.293, p=0.033). CONCLUSION: Elevated liver enzyme were positively correlate with coagulation abnormalities in children with DVI.