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Abstract Ref Number = APCP121
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Neurodevelopmental monitoring and outcome of congenital infection
SetyoHandryastuti
Neurology Division,Department of Child HealthCiptoMangunkusumo Hospital
Medical FacultyUniversity of Indonesia, Jakarta
Congenital infections, such as cytomegalovirus (CMV) and toxoplasmosis congenital (CT) causes a spectrum of impairments, including sensorineural hearing loss (SNHL), vision loss, and developmental problems. Developmental problems could be cerebral palsy, global developmental delay, behavioural problems and intellectual disability. Neurodevelopmental monitoring was very important especially in the first year of life. Screening and assessment of developmental problems should be done regularly and early intervention can be done. The other complication such as hearing and visual problems can develop later in life. In the United States, an estimated 20.000 (0.5%) children are born with congenital CMV infection annually.Although the majority (85%–90%) appear asymptomatic at birth, SNHL may be present at birth, progress in severity, or develop later.The extent to which asymptomatic congenital CMV infection is associated with increased risk of intellectual impairment or low academic achievement throughout childhood. The incidence of CT rises to 60-80% in late pregnancy with fetal lesions that mainly consist of toxoplasmicchorioretinitis. These lesions may also appear later during childhood or early adulthood and occasionally jeopardize visual function. Long-term follow-up of children with CT is important for a good ocular and neurological prognosis. The percentage of children with chorioretinitistoxoplasmosis undoubtedly increases with the duration of follow-up. It is therefore important to emphasize to the parents, and also to pediatricians and ophthalmologists, the need to continue follow-up for more than 10 years.Long‐term follow‐up to at least until school age for hearing, visual and neurodevelopment is necessary.
Keywords: congenital infection-developmental monitoring-hearing loss-chorioretinitis
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