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Abstract Ref Number = APCP252
Oral Presentation
VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION ON ACUTE LYMPHOBLASTIC ACUTE INDUCTION PHASE CHEMOTHERAPY RESPONSE
Merlyn Meta Astari,Dasril Daud,Nadirah Rasyid Ridha,Syarifuddin Rauf,Hadia Angriani,Amiruddin L
Department of Child Health Faculty of Medicine Hasanuddin University Makassar
Background : Leukemia is a hematolymphoid malignancies originates from bone marrow. Hematolymphoid malignancies progression depend on new vasculature formation called angiogenesis. Angiogenesis factor regulated by Vascular Endothelial Growth Factor (VEGF) secreted by paracrine and autocrine pathway. This study aimed to evaluate Vascular Endothelial Growth Factor (VEGF) expression on Acute Lymphoblastic Leukemia (ALL) induction phase of chemotherapy.
Material : This cohort prospective study was conducted to all ALL patients that admitted to Dr. Wahidin Sudirohusodo Hospital from October 2016 to October 2017. VEGF level was measured at diagnosis and at the end of induction chemotherapy.
Results : VEGF levels were analyzed in 59 patients, 29 patients were diagnosed ALL standard risk and 30 patients were high risk. VEGF levels were significantly decreased after induction phase of chemotherapy in ALL standard risk (p=0.000) and in ALL high risk (p=0.001). There was no significant difference in VEGF levels before induction phase of chemotherapy between ALL standard risk and high risk group (p=0.405). There was no significant difference in VEGF levels after induction phase of chemotherapy between ALL strandard risk and high risk group (p=0.094).
Conclusions : VEGF level was significantly lower after ALL induction phase chemotherapy both in ALL standard risk and high risk. There was no significant difference of VEGF level before and after induction phase of chemotherapy in ALL standard risk and high risk group.
Keywords: angiogenesis acute lymphoblastic leukemia VEGF
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