Yeni Konga Ala Kula Awang,Gatot Irawan Sarosa
RSUP dr Kariadi Department of Pediatrics, Faculty of Medicine, Diponegoro UniversityDr Kariadi Hospital, Semarang, Indonesia
Background : Prematurity is well known to be associated with higher rates of neonatal hypoglycemia. The aim of this study was to detect the incidence and the risk factors of hypoglycaemia in preterm newborn. Early identification of hypoglycemia risk factors are important for long term outcomes.
Material : We conducted a case control study. Medical record of preterm infants (<37 weeks of gestational age), admitted to Kariadi Hospital Semarang between January and December 2017 were retrospectively reviewed. The diagnosed of neonatal hypoglycemia was based on clinical manifestation and laboratory examination. Hypoglycemia was defined as blood glucose levels < 47 mg/dL with in 48 hours of life. Statistic analysis was peformed by using Pearson chi – square test and multivariate analysis.
Results : There were 244 preterm newborn, 66 (27%) pretem newborns were found have hypoglycemia. Among the preterm newborn with hypoglycemia : 31 (47%) were boys and 35 (53%) were girls, 16 (24.2%) were born from high risk mother, 38 (57.6%) moderate to late preterm, 43 (65.2%) were multiple gestational, 30 (45.5%) with preeclampsia/eclampsia, 39 (59.1%) were born by sectio caesaerean, 45 (68.2%) were appropriate gestational age. Thirty eights (57.6 %) were low birth weight, 33 (50%) were vigorous baby and 9 (13.6%) were twins. We found preeclampsia/eclampsia (OR 2.83; CI 95% = 1.34 – 6.013) and small for gestational age (OR 4.56; CI 95% = 1.42 – 14.59) were statistically different between case group and control group. Normal birth weight was found as a protective factor. Multivariate analysis disclosed that small for gestational age was significantly predominant associated with hypoglycemia in preterm newborn.
Conclusions : Small for gestational age was significantly risk factor associated with hypoglycemia in preterm newborn.